Nagen is a unique formula developed exclusively for California based company, Live Cell Research. Designed as a comprehensive anti-aging formula, Niagen promotes healthy and youthful overall function of every system in the body, as well as vital organ function through boosting levels of a compound known as NAD+ (nicotinamide adenine dinucleotide). This is done through its precursor, Vitamin B3, otherwise known as nicotinamide riboside. Researchers know that age-related decline of this compound is linked to a variety of potential health problems including neurodegeneration, cardiovascular events, and even DNA damage.1 However, scientists have recently discovered that NAD+ levels can be restored through supplementation of Nicotinamide riboside (Vitamin B3) – the same compound found inside the Niagen formula!2 How Does Niagen Work? The age-related decline of NAD+ production is very common in most people. However, there are many different consequences of decline in NAD+ levels and the related loss of vital enzymes known as SIRT’s. They can include these 5 health concerns: 1. Neurodegeneration. NAD+ performs many functions in the body, one of which is regulating the enzymes that consume it, including what are known as sirtuins or SIRT’s. Together, Vitamin B3, and SIRT1 work to regulate metabolism and circadian rhythm – two vital body processes that commonly deteriorate with age. However, age-related NAD+ decline is associated with a number of neurodegenerative health problems stemming from cellular dysfunction. This suggests that when supplementing with Vitamin B3 (NAD’s+ precursor) you may be able to counteract age-associated risk factors of neurodegeneration.3,4 2. Vascular Inflammation. The cardiovascular system can be bombarded by a number of health issues as we age. In fact, cardiovascular disease is the #1 killer of both men and women worldwide.5 For this reason, it is very important that you consider the protective role of NAD+. Numerous studies have shown that a lack of NAD+ production may be associated with a range of cardiovascular risk factors including damage to blood vessels.6,7 3. Liver Damage. Fat storage does not just happen around your mid-section. In fact, fat accumulation can also occur inside your liver, increasing your risk of cholesterol buildup and fatty liver disease.8,9 4. Insulin Resistance. Low levels of NAD+ and the associated reduction in SIR’s may prevent healthy cells from effectively removing sugar from the bloodstream.10,11 This often results in higher blood sugar levels--a component of metabolic syndrome.12 5. Fatigue/Loss of Muscle Strength. Without enough NAD+ production, fatty acids may not be properly oxidized in the body, depriving the body of its most vital natural energy sources: fat.13,14 Niagen works to replenish lost stores of NAD+ by adding 250 mg of its pre-cursor known as nicotinamide riboside to your body for absorption. With use, you may be able to reduce risk for some of these health problems. Not only that, researchers also know that Vitamin B3 extends life span and may also increase/enhance endurance, cognitive function, and cellular energy.15,16 Can Niagen Work for Me? Vitamin B3 is a nutrient needed for an estimated 400+ enzymatic reactions in the body. Essential for energy production and cellular communication, a new form of this vitamin called nicotinamide riboside, found inside every bottle of Niagen, may help to boost NAD+ levels and restore damaged tissues. This can work to offer anti-aging benefits to anyone who desires to increase the amount of NAD+ in their bodies. Boosting NAD+ levels with Vitamin B3 is one way to directly approach your health with an effective strategy for youthful vitality. So, talk to your doctor today about adding Niagen to your everyday health regimen. There is no better time! References: 1. Shin-ichiro Imai, Leonard Guarente. NAD+ and Sirtuins in Aging and Disease Shin-ichiro Imai1 and Leonard Guarente. Trends Cell Biol. 2014 Aug; 24(8): 464–471. 2. Samuel A. J. Trammell, Mark S. Schmidt. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications 7, Article number: 12948 (2016). 3. Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014 Aug;24(8):464-71. 4. Min SW, Sohn PD. Sirtuins in neurodegenerative diseases: an update on potential mechanisms. Front Aging Neurosci. 2013 Sep 25;5:53. 5. World Health Organization. Cardiovascular diseases (CVDs). May 2017. 6. Oellerich MF, Potente M. FOXOs and sirtuins in vascular growth, maintenance, and aging. Circ Res. 2012 Apr 27;110(9):1238-51. 7. Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol. 2010;5:253-95. 8. Tao R, Wei D, Gao H. Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene. J Biol Chem. 2011 Apr 22;286(16):14681-90. 9. Arguello G, Balboa E. Recent insights on the role of cholesterol in non-alcoholic fatty liver disease. Biochim Biophys Acta. 2015 Sep;1852(9):1765-78. 10. Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol. 2010;5:253-95. 11. Frojdo S, Durand C, Molin L, et al. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Mol Cell. 12. Sasaki T, Kim HJ, Kobayashi M, et al. Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide. Endocrinology. 2010 Jun;151(6):2556-66. 13. Feige JN, Lagouge M, Canto C, et al. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab. 2008 Nov;8(5):347-58. 14. Green MF, Hirschey MD. SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome. J Gerontol A Biol Sci Med Sci. 2013 Feb;68(2):105-7. 15. Belenky P, Racette FG. Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Cell. 2007 May 4;129(3):473-84. 16. Carles Cantó, Riekelt H. Houtkooper. The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity. Cell Metab. 2012 Jun 6; 15(6): 838–847.
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